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Immunofluorescence analysis of rat sperm demonstrated that SP-GPX5 was able to bind to the sperm head during epididymal transit and ejaculation [21], hypothesizing that this enzyme could prevent premature acrosome reactions once sperm are delivered into the female reproductive tract by binding GPX5 to membrane lipid peroxides, preventing the interaction between these peroxides and phospholipase A2 [32]

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